The Adhesome Network: Key Components Shaping the Tumour Stroma

Nikolopoulou, Pinelopi A. and Koufaki, Maria A. and Kostourou, Vassiliki (2021) The Adhesome Network: Key Components Shaping the Tumour Stroma. Cancers, 13 (3). p. 525. ISSN 2072-6694

[thumbnail of cancers-13-00525-v3.pdf] Text
cancers-13-00525-v3.pdf - Published Version

Download (1MB)


Beyond the conventional perception of solid tumours as mere masses of cancer cells, advanced cancer research focuses on the complex contributions of tumour-associated host cells that are known as “tumour microenvironment” (TME). It has been long appreciated that the tumour stroma, composed mainly of blood vessels, cancer-associated fibroblasts and immune cells, together with the extracellular matrix (ECM), define the tumour architecture and influence cancer cell properties. Besides soluble cues, that mediate the crosstalk between tumour and stroma cells, cell adhesion to ECM arises as a crucial determinant in cancer progression. In this review, we discuss how adhesome, the intracellular protein network formed at cell adhesions, regulate the TME and control malignancy. The role of adhesome extends beyond the physical attachment of cells to ECM and the regulation of cytoskeletal remodelling and acts as a signalling and mechanosensing hub, orchestrating cellular responses that shape the tumour milieu.

Item Type: Article
Subjects: Middle East Library > Medical Science
Depositing User: Unnamed user with email
Date Deposited: 20 Jan 2023 09:01
Last Modified: 29 Apr 2024 07:49

Actions (login required)

View Item
View Item