Down Presymptomatic View of Dementia Characteristics

Joshaghanian, Mohammad Amin and Mohammadi, Sassan and Gholizadeh Ghozloujeh, Zohreh and Farahani, Mehrdad and Mojtabavi, Kurosh (2019) Down Presymptomatic View of Dementia Characteristics. International Clinical Neuroscience Journal, 7 (1). pp. 1-5. ISSN 2383-1871

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Down syndrome (DS) is caused by complete or segmental chromosome 21 trisomy that results in neurodegeneration and progressive intellectual disability. Abnormal function in the prefrontal cortex, cerebellum, and hippocampus are the main reasons for cognitive deficits in DS that result in impaired cognitive function, delayed speech and language, learning and memory disability, and behavioral and emotional disorders. There is no specific treatment for DS, and our understanding of the mechanisms of the disorder is incomplete and causes to hamper the development of effective therapies regarding the development of neuropathology and memory loss in DS. Here, we review the literature on cognitive functioning, unique characteristics, environmental considerations, and recent findings on Alzheimer’s disease in DS.

Item Type: Article
Subjects: Middle East Library > Medical Science
Depositing User: Unnamed user with email
Date Deposited: 21 Jan 2023 07:07
Last Modified: 02 May 2024 06:14

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