Anthelmintic Screening of Hylocereus polyrhizus Rind Extracts

The purpose of this study was to evaluate the rind extract of Hylocereus polyrhizus's anthelmintic efficacy. Ethanol and water were utilized to extract the powdered rind of H. polyrhizus. The phytochemical screening of H. polyrhizus ethanol extract (HPEE) and water extract (HPAE) was done. The adult motility assay and resistance-modifying study were then used to screen for the plant's anthelmintic properties against Eudrilus eugeniae. Due to its morphological and physiological resemblance to the human intestinal roundworm, Eudrilus eugeniae was chosen in the investigation. On E. eugeniae, HPEE and HPAE demonstrated dose-dependent paralytic and fatal effects. The anthelminthic activity of albendazole was also assessed by HPEE and HPAE through resistance-modifying research and the adult worm (E. eugeniae) motility assay. The addition of different concentrations of HPEE and HPAE considerably (p < 0.05) increased the activity of albendazole against E. eugeniae. Against E. eugeniae, they exhibited dose-dependent anthelmintic action. When compared to HPEE, HPAE exhibits the strongest activity. Albendazole's lethality and paralytic action were considerably increased by HPEE and HPAE. HPEE and HPAE underwent phytochemical screening, which identified the presence of coumarins, alkaloids, glycosides, tannins, and saponins. The findings of this investigation demonstrate the anthelmintic activity of H. polyrhizus.