Advanced Strategies for Unnatural Amino Acid Synthesis and their Applications in Chemistry and Biotechnology

Unnatural Amino Acids (UAA) are key structural units of various natural products, bioactive molecules, and drugs. Chiral pool, asymmetric synthesis, and racemic synthesis were explored in the synthesis of UAA. UAA plays a very important role in bioconjugation, organocatalysis, labelling of bacterial cells, etc. UAA is used in bioconjugation for attaching fluorophore and small molecules for labelling and drug delivery. Here in this chapter, we discuss the recent synthesis of unnatural amino acids and their applications in total synthesis and biological studies.