Biochemical Changes and Fatigability in Albino Rats after Oral Administration of Adenosine Triphosphate

Objective: The study was undertaken to evaluate the biochemical changes and fatigability in albino rats after oral administration of adenosine triphosphate (ATP).

Study Design: Animal experimental study.

Place of Study: Department of Biochemistry and Pharmacology, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India.

Methods: Twelve Swiss albino rats of either gender weighing between 200 to 300 gm were taken. Animals were grouped randomly into two groups consisting of 6 rats each. Group –I received distilled water (5 ml/kg body weight) and Group-II ATP orally at the dosage of 60mg/kg body weight for 8 days. On 8th day of experiment, all animals were evaluated for extent of physical fatigue by using exhaustive swimming test. The blood samples were collected and blood sugar, urea, uric acid, hsCRP, total cholesterol and triglyceride were measured.

Results: There was a significant (p<0.05) increase in serum uric acid, blood sugar and urea in Group- II as compared to Group- I.

Conclusion: Oral administration of ATP may lead to hyperglycaemia, hyperuricemia and dyslipidaemia.