Sperm DNA Fragmentation as a Factor of Male Low Reproductive Function in IVF Practice

The correlation between semen DNA fragmentation level and the male age was investigated. The dependence for the blastocyst formation rates on the sperm DNA fragmentation has been examined in patients with low reproductive function. The increase of DNA fragmentation level correlates with the decrease of the blastocyst formation rates (p < 0.05). The significant negative relationship between sperm DNA fragmentation and the male age is proved (p < 0.05). The age of 35 years old could be discussed as clinically critical male age for the process of chromatin compaction during the process of spermatogenesis.